Endocrine Abstracts

Introduction: Many patients with diabetes experience high variability in glucose concentrations which is associated with a risk of hypoglycemia. The aim of this was to compare the predictive value of HbA1C, mean interstitial glucose (MIG), and glucose variability (GV) in the risk of hypoglycemia in patients with type 1 diabetes (T1D).Methods: Continuous glucose monitoring, using CGMS system, was performed in 130 T1D patients with diabetes duration of 17....

Introduction: Renal function and glucose lowering therapy, particularly metformin, influence serum lactate concentration in patients with type 2 diabetes (T2D). However, seems to be an acute precipitating event that triggers hyperlactacidemia and metabolic acidosis. This study aims to assess prevalence of hyperlactacidemia in T2D patients who presented at emergency room (ER), calculate relative risk of hyperlactacidemia in diabetics under metformin, identify predictive factors...

Introduction: Thyroglobulin (TG) measurement in fine needle aspirates cytology (FNAC) needle washout has become an important method for diagnostic of cervical lymph nodes, particularly in patients with differentiated thyroid cancers, but also in some patients before the diagnostic. We report some clinical cases to confirm its importance in these situations.Patients and methods: In our department we use this method since 2007. We report seven patients wit...

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcaemia in the outpatient setting. Surgical remove of an adenoma or hyperplastic glands results in cure, but an accurate localization, preoperative whenever possible, is essential for success. Taking into consideration that parathyroid carcinoma is a rare event, FNA of parathyroid glands, complemented by PTH measurement in washouts (FNA/PTH), may be a useful tool in the diagnostic workout.<...

Progression of metabolic syndrome to diabetes is not easily predicted in patients with morbid obesity. We hypothesized that no insulin-resistance is more usual as we thought.Objective: Evaluate prevalence of no insulin-resistance status in patients with morbid obesity.Patients and method: The study was undertaken in 130 patients with a BMI of 53.93±6.67 kg/m2. The morbidly obese patients were divided into four group...

Introduction: Adrenal hematomas are very rare entities. They occur often associated with: trauma, anticoagulation, coagulopathy, septicemia, pregnancy complications or tumors. When none of these predisposing factors is present, diagnosis and treatment can become a real challenge.Case report: A 19-years-old woman presented with complaints of asteny, loss of appetite, loss of 10 kg in a month, and pain in right lumbar and abdominal regions. No other compla...

Pheochromocytomas are rare, catecholamine-secreting, adrenal neoplasms. In about 25% of cases they arise in patients with germline mutations. Malignancy occurs in about 10%.We retrospectively analysed the records of patients with histological diagnosis of pheochromocytoma submitted to adrenal surgery between 1987–2008 and followed in the Endocrinology department.Thirteen patients were included. We evaluated age on diagnosis; c...

Introduction: After treatment with Iodine-131(I-131) in differentiated thyroid cancer, a diagnostic scintigraphy is performed. We selected three cases in which bronchiectasis appear as a false-positive on the scintigraphy after treatment with I-131.Case reports: Three women, respectively 62, 64 and 65 years old, being followed in the Endocrinology Department of our Institute, with the diagnosis of papillary carcinoma of the thyroid, were submitted to I-1...

Introduction: Anaplastic thyroid carcinoma, either by its low frequency, or by its poor prognosis, is still as a therapeutic challenge. One of the options available is the combined chemoradiation therapy, the basis of the following case.Case report: Male patient, 76 years old, with a history of neck swelling for 4 months. The cervical ultrasound showed a nodule in the right lobe of the thyroid with 7 by 5 cm and the cytology revealed follicular tumor. Su...

Association between anorexia nerviosa (AN) and low bone mass has been demonstrated. Bone loss associated with AN involve hormonal and nutritional impairments, though their exact contribution is not clearly established. We compare bone mass in AN patients with women of similar weight with no criteria for anorexia nervosa, and a third group of healthy, normal-weight, age-matched women. The study included 48 patients with AN (DSM-IV criteria), 22 healthy eumenorrheic women with l...